ParkinsonCanadaV1, France, Analysis, bibRecord, 000081

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Identifieur interne : 000081 ( France/Analysis ); précédent : 000080; suivant : 000082

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Auteurs : Nadine Schweizer [Suède] ; Stéfano Pupe [Suède, Brésil] ; Emma Arvidsson [Suède] ; Karin Nordenankar [Suède] ; Casey J. A. Smith-Anttila [Suède] ; Souha Mahmoudi [Canada] ; Anna Andrén [Suède] ; Sylvie Dumas [France] ; Aparna Rajagopalan [Suède] ; Daniel Lévesque [Canada] ; Richardson N. Leão [Suède, Brésil] ; Sa Wallén-Mackenzie [Suède]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.

RBID : PMC:4040590

English descriptors

KwdEn :
- Animals, Dopamine (metabolism), Excitatory Postsynaptic Potentials (physiology), Glutamic Acid (metabolism), Homeodomain Proteins (metabolism), Hyperkinesis (etiology), Hyperkinesis (metabolism), Immunohistochemistry, In Situ Hybridization, Maze Learning (physiology), Mice, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Subthalamic Nucleus (metabolism), Synaptic Transmission (physiology), Transcription Factors (metabolism), Vesicular Glutamate Transport Protein 2 (metabolism).
MESH :
- chemical , metabolism : Dopamine, Glutamic Acid, Homeodomain Proteins, Transcription Factors, Vesicular Glutamate Transport Protein 2.
- etiology : Hyperkinesis.
- metabolism : Hyperkinesis, Subthalamic Nucleus.
- physiology : Excitatory Postsynaptic Potentials, Maze Learning, Synaptic Transmission.
- Animals, Immunohistochemistry, In Situ Hybridization, Mice, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

Significance

The subthalamic nucleus (STN) has an important role in locomotion, as evidenced by the successful use of high-frequency stimulation of this structure as treatment for Parkinson disease. There is considerable uncertainty, however, regarding the mechanism through which this effect is achieved. We identified a promoter diversity within this nucleus and observed a movement phenotype displayed as decreased latency in initiation of movement and increased locomotion in both horizontal and vertical planes as a consequence of blunting, but not eliminating, expression of Vglut2 in the STN of mice. In contrast to various lesion and high-frequency-stimulation studies of the STN, our genetic approach leaves cognitive functions intact. Taken together, our findings could be important for advancing future therapeutic strategies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040590

DOI: 10.1073/pnas.1323499111
PubMed: 24821804
PubMed Central: 4040590

Affiliations:

Brésil, Canada, France, Suède

Links to Exploration step

PMC:4040590

Le document en format XML

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 H3C 3J7</nlm:aff>
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;</nlm:aff>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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 H3C 3J7</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Andren, Anna" sort="Andren, Anna" uniqKey="Andren A" first="Anna" last="Andrén">Anna Andrén</name>
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, S-751 24 Uppsala,<country>Sweden</country>
;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Dumas, Sylvie" sort="Dumas, Sylvie" uniqKey="Dumas S" first="Sylvie" last="Dumas">Sylvie Dumas</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, S-751 24 Uppsala,<country>Sweden</country>
;</nlm:aff>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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 H3C 3J7</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Leao, Richardson N" sort="Leao, Richardson N" uniqKey="Leao R" first="Richardson N." last="Leão">Richardson N. Leão</name>
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, S-751 24 Uppsala,<country>Sweden</country>
;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3">Brain Institute,<institution>Federal University of Rio Grande do Norte</institution>
, 2155-59056-450 Natal-RN,<country>Brazil</country>
;</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Wallen Mackenzie,  Sa" sort="Wallen Mackenzie,  Sa" uniqKey="Wallen Mackenzie  " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
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, S-751 24 Uppsala,<country>Sweden</country>
;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2014">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Dopamine (metabolism)</term>
<term>Excitatory Postsynaptic Potentials (physiology)</term>
<term>Glutamic Acid (metabolism)</term>
<term>Homeodomain Proteins (metabolism)</term>
<term>Hyperkinesis (etiology)</term>
<term>Hyperkinesis (metabolism)</term>
<term>Immunohistochemistry</term>
<term>In Situ Hybridization</term>
<term>Maze Learning (physiology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Subthalamic Nucleus (metabolism)</term>
<term>Synaptic Transmission (physiology)</term>
<term>Transcription Factors (metabolism)</term>
<term>Vesicular Glutamate Transport Protein 2 (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Glutamic Acid</term>
<term>Homeodomain Proteins</term>
<term>Transcription Factors</term>
<term>Vesicular Glutamate Transport Protein 2</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hyperkinesis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hyperkinesis</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Excitatory Postsynaptic Potentials</term>
<term>Maze Learning</term>
<term>Synaptic Transmission</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Immunohistochemistry</term>
<term>In Situ Hybridization</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>The subthalamic nucleus (STN) has an important role in locomotion, as evidenced by the successful use of high-frequency stimulation of this structure as treatment for Parkinson disease. There is considerable uncertainty, however, regarding the mechanism through which this effect is achieved. We identified a promoter diversity within this nucleus and observed a movement phenotype displayed as decreased latency in initiation of movement and increased locomotion in both horizontal and vertical planes as a consequence of blunting, but not eliminating, expression of <italic>Vglut2</italic>
 in the STN of mice. In contrast to various lesion and high-frequency-stimulation studies of the STN, our genetic approach leaves cognitive functions intact. Taken together, our findings could be important for advancing future therapeutic strategies.</p>
</div>
</front>
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<affiliations><list><country><li>Brésil</li>
<li>Canada</li>
<li>France</li>
<li>Suède</li>
</country>
</list>
<tree><country name="Suède"><noRegion><name sortKey="Schweizer, Nadine" sort="Schweizer, Nadine" uniqKey="Schweizer N" first="Nadine" last="Schweizer">Nadine Schweizer</name>
</noRegion>
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<name sortKey="Arvidsson, Emma" sort="Arvidsson, Emma" uniqKey="Arvidsson E" first="Emma" last="Arvidsson">Emma Arvidsson</name>
<name sortKey="Leao, Richardson N" sort="Leao, Richardson N" uniqKey="Leao R" first="Richardson N." last="Leão">Richardson N. Leão</name>
<name sortKey="Nordenankar, Karin" sort="Nordenankar, Karin" uniqKey="Nordenankar K" first="Karin" last="Nordenankar">Karin Nordenankar</name>
<name sortKey="Pupe, Stefano" sort="Pupe, Stefano" uniqKey="Pupe S" first="Stéfano" last="Pupe">Stéfano Pupe</name>
<name sortKey="Rajagopalan, Aparna" sort="Rajagopalan, Aparna" uniqKey="Rajagopalan A" first="Aparna" last="Rajagopalan">Aparna Rajagopalan</name>
<name sortKey="Smith Anttila, Casey J A" sort="Smith Anttila, Casey J A" uniqKey="Smith Anttila C" first="Casey J. A." last="Smith-Anttila">Casey J. A. Smith-Anttila</name>
<name sortKey="Wallen Mackenzie,  Sa" sort="Wallen Mackenzie,  Sa" uniqKey="Wallen Mackenzie  " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name>
</country>
<country name="Brésil"><noRegion><name sortKey="Pupe, Stefano" sort="Pupe, Stefano" uniqKey="Pupe S" first="Stéfano" last="Pupe">Stéfano Pupe</name>
</noRegion>
<name sortKey="Leao, Richardson N" sort="Leao, Richardson N" uniqKey="Leao R" first="Richardson N." last="Leão">Richardson N. Leão</name>
</country>
<country name="Canada"><noRegion><name sortKey="Mahmoudi, Souha" sort="Mahmoudi, Souha" uniqKey="Mahmoudi S" first="Souha" last="Mahmoudi">Souha Mahmoudi</name>
</noRegion>
<name sortKey="Levesque, Daniel" sort="Levesque, Daniel" uniqKey="Levesque D" first="Daniel" last="Lévesque">Daniel Lévesque</name>
</country>
<country name="France"><noRegion><name sortKey="Dumas, Sylvie" sort="Dumas, Sylvie" uniqKey="Dumas S" first="Sylvie" last="Dumas">Sylvie Dumas</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000081 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000081 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:4040590
   |texte=   Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:24821804" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.